tag:blogger.com,1999:blog-3023805782808412230.post7447027666308372397..comments2024-03-09T15:46:44.638+01:00Comments on For what they were... we are: HERC2 haplotypes, phylogeny and frequenciesMajuhttp://www.blogger.com/profile/12369840391933337204noreply@blogger.comBlogger11125tag:blogger.com,1999:blog-3023805782808412230.post-49613237040621278322013-06-25T13:29:13.031+02:002013-06-25T13:29:13.031+02:00Map corrected: there was an error in the Swedish c...Map corrected: there was an error in the Swedish chart (h/t to Davidski). Majuhttps://www.blogger.com/profile/12369840391933337204noreply@blogger.comtag:blogger.com,1999:blog-3023805782808412230.post-89882324360111617452013-06-25T12:07:07.465+02:002013-06-25T12:07:07.465+02:00Updated with map.Updated with map.Majuhttps://www.blogger.com/profile/12369840391933337204noreply@blogger.comtag:blogger.com,1999:blog-3023805782808412230.post-72725197289057910352013-06-10T13:52:32.018+02:002013-06-10T13:52:32.018+02:00Indeed, my bad. A typo or lapsus happened there an...Indeed, my bad. A typo or lapsus happened there and I'll correct immediately. Thanks for noticing. Majuhttps://www.blogger.com/profile/12369840391933337204noreply@blogger.comtag:blogger.com,1999:blog-3023805782808412230.post-47758569370137725682013-06-10T12:34:45.744+02:002013-06-10T12:34:45.744+02:00Maju wrote, "In West Asia and Pakistan (the m...Maju wrote, "In West Asia and Pakistan (the most plausible ancient origin of the trait), we see how the ancestral #1 variant is generally dominant, with the only exception of the Kalash, reaching the highest frequencies (18%) among the Brahui and Palestinians, among the studied populations."<br /><br />The highest frequencies of the "Branch #1" variant among the listed populations from West Asia or Pakistan are from the Palestinians and <i>Burushos</i>, not the Brahuis. The Brahuis actually exhibit the lowest frequency of the "Branch #1" variant among the listed populations.<br /><br />Of course, the classification of Adygea as part of "Europe" as opposed to "West Asia" is quite arbitrary, but so be it.Ebizurhttps://www.blogger.com/profile/16925110639823856429noreply@blogger.comtag:blogger.com,1999:blog-3023805782808412230.post-41857786554485101742013-06-10T00:19:50.921+02:002013-06-10T00:19:50.921+02:00Yes I think that you are right in that the genetic...Yes I think that you are right in that the genetics behind hazel (mixed brown and green) eyes are not truly known yet. It is hard to say but do you know if hazel eyes are classified usually as being light or dark eyes? I would say dark because the brown usually stands out more and the green is only really seen in bright light conditions or up close.jackson_montgomery_devonihttps://www.blogger.com/profile/17553257488930856466noreply@blogger.comtag:blogger.com,1999:blog-3023805782808412230.post-68515965200823180722013-06-09T21:26:48.168+02:002013-06-09T21:26:48.168+02:00I have the impression that hazel and green eyes im...I have the impression that hazel and green eyes imply intermediate pigmentation between brown and blue. However, unlike blue eyes, for which a single SNP variant seems to be responsible of the vast majority of cases (and almost invariably causes blue eyes), for these other color variants the exact genetic triggers are not well understood yet. <br /><br />There have been a couple of recent studies, on Cape-Verdeans and Europeans respectively, that may help in the understanding of what is known and what is still unknown about (Western) human pigmentation, including eye color:<br /><br />http://forwhattheywereweare.blogspot.com.es/2013/04/eye-and-skin-pigmentation-genetics-cape.html<br /><br />http://forwhattheywereweare.blogspot.com.es/2012/11/causes-of-skin-and-hair-color-variance.html<br /><br />In the Cape Verde study, besides HERC2, there was also some notable correlation of eye color with SLC24A5, which is even more important in skin pigmentation. In the European study, a gene called SIN, appears to have also some correlation with eye color, something that was not known before. These may well be (speculatively speaking) causes of exceptions to the HERC2 "rule" and may also influence other shades of eye color.<br /><br />Majuhttps://www.blogger.com/profile/12369840391933337204noreply@blogger.comtag:blogger.com,1999:blog-3023805782808412230.post-92131572366951409322013-06-09T21:07:49.322+02:002013-06-09T21:07:49.322+02:00"23andme: "AG at rs12913832: IN EUROPEAN..."23andme: "AG at rs12913832: IN EUROPEANS, 56% chance of brown eyes; 37% chance of green eyes; 7% chance of blue eyes.""<br /><br />Better than SNPedia. There must be some other alleles at play, what is in itself interesting. <br /><br />"Thanks Maju for spreading the word".<br /><br />No. Thanks to you for your excellent and most interesting work.Majuhttps://www.blogger.com/profile/12369840391933337204noreply@blogger.comtag:blogger.com,1999:blog-3023805782808412230.post-70656357095338525192013-06-09T21:05:24.833+02:002013-06-09T21:05:24.833+02:00According to SNPedia: "AG at rs1291383" ...<a href="http://www.snpedia.com/index.php/Rs12913832" rel="nofollow">According to SNPedia</a>: "AG at rs1291383" equals "brown eye color". I guess there may be a small chance of some other outcome but, generally speaking, Palisto does not seem to be too wrong. <br /><br />Said that, I understand that other research and particular exceptional data, like yours, must be cross-checked in order to improve understanding, but I guess that your light blue eyes must be caused by some other allele or combo. Majuhttps://www.blogger.com/profile/12369840391933337204noreply@blogger.comtag:blogger.com,1999:blog-3023805782808412230.post-41044738361594072032013-06-09T20:14:16.527+02:002013-06-09T20:14:16.527+02:00Interesting little analysis here. Here are my fami...Interesting little analysis here. Here are my family members results for these SNPs.<br /><br />rs12913832<br /><br />Father: AA<br />Mother: GG<br />Uncle (father's brother): AG<br />Me: AG<br />Brother: AG<br /><br />rs1129038 <br /><br />Father: CC<br />Mother: TT<br />Uncle (father's brother): CT<br />Me: CT<br />Brother: CT<br /><br />Now my father has pure brown eyes which seems to match his results quite well. My mother has blue eyes which also seems to match her results quite well. My uncle, brother and I all have the same results for these SNPs but my uncle and I both have hazel eyes whereas my brother has pure brown eyes. That is my uncle's and my own eyes have a light brown ring around the pupil in the center and then they are green on the outside. My brother on the other hand has no green in his eyes. They are pure brown.jackson_montgomery_devonihttps://www.blogger.com/profile/17553257488930856466noreply@blogger.comtag:blogger.com,1999:blog-3023805782808412230.post-80507811782874400012013-06-09T17:54:40.533+02:002013-06-09T17:54:40.533+02:00My focus is Kurdish DNA. From my observations I kn...My focus is Kurdish DNA. From my observations I know that in Kurds AG at rs12913832 always results in brown eye color. This phenotype outcome is probably true for most Asian populations. <br />Example: 40% of Turks (N=112) are AG or GG at rs12913832 but not 40% of Turks have blue/green eyes.<br /><br />Only in European populations with lighter skin colors AG at rs12913832 can results in green and even blue in some rare cases.<br /> <br />23andme: "AG at rs12913832: IN EUROPEANS, 56% chance of brown eyes; 37% chance of green eyes; 7% chance of blue eyes."<br /><br />Thanks Maju for spreading the word.Palistohttps://www.blogger.com/profile/05633640722962576468noreply@blogger.comtag:blogger.com,1999:blog-3023805782808412230.post-19469896415996384572013-06-09T17:05:55.048+02:002013-06-09T17:05:55.048+02:00Palisto is wrong.
I have AG at rs12913832 and my ...Palisto is wrong.<br /><br />I have AG at rs12913832 and my eyes are light blue without any brown spots.<br /><br />Probably GG at rs12913832 means slightly higher probability of blue eyes, but definitely AG at rs12913832 does not result in brown eyes.<br />Bolekhttps://www.blogger.com/profile/05640796790204017716noreply@blogger.com